Donna Lou Who is a character in the 2018 Illumination animated film version of The Grinch. She is the mother of Cindy Lou Who and twin infant sons, Buster and Bean. She seems to be very loosely based on Betty Lou Who and Martha May Whovier from the live-action version.

Every night, she works overtime as a hospital nurse until morning and tries her best to catch the bus since she's so tired. At her house, she was making breakfast, trying to get something at the sink and overworked trying to take care of Cindy and her twin infant brothers, Bean and Buster.

She really loves her children and does everything to the best of her ability to be happy especially on Christmas. Before The Grinch steals Christmas, she was tucking Cindy into bed and told Cindy that whatever she asks Santa for Christmas, it must be really important to her (which it is since Cindy’s only wish is to lighten her mother's workload since she always helps others).

The next morning, after the Grinch has stolen everything, the Whos wake up and are shocked to see that the presents and decorations are gone. Cindy at first believes she's to blame because she caught Santa, but Donna tells her that Christmas is more than just about presents and that Cindy's the best thing that ever happened to her since she helps her mother out with her workload and the Whos join in singing.

After the Grinch returns everything he stole and apologizes for the theft, Cindy comes to invite him over to dinner at her house and he awkwardly attends. After he did, Donna was happy that he decided to come, welcome him, told him that he wear a nice necktie and told Cindy that he came.

Later, Donna was having a hard time, holding the foods until the Grinch helped her out and Donna was surprised at this by saying "Oh, that was very sweet of him".

When seated down for dinner, Donna told the Grinch if he can carves the roast beast. The Grinch admits that, in the end, it wasn't really Christmas he disliked but being lonely, and tells Donna that Cindy was the first person to show him some kindness. The Grinch, along with Max, then celebrates Christmas with the Whos and starts a new life with them, especially with Cindy and her family.

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