Pinky and the Brain is a cartoon series that ran from 1995 to 1998 and had two Christmas-themed episodes.
A Pinky and the Brain Christmas
The first of the two, "A Pinky and the Brain Christmas", first aired on December 13, 1995.
In his latest attempt to take over the world, the Brain disguises himself and Pinky as two of Santa's elves and get jobs in the list processing section of Santa's workshop. There, Pinky adds a "Noodle Noggin" doll to everyone's wish list. He will use the mind control device in the doll to control everyone. Pinky just wants to give Santa his list and misses the opportunity. When the Brain gains control of all the people of the world, he sees Pinky's note, wanting only a Merry Christmas for Brain. Brain is so touched he commands everyone to have a Merry Christmas, and then destroys the control machine.
Yule Be Sorry
A second Christmas cartoon starring the mice was done for the series' continuation, Pinky, Elmyra and the Brain, when the mice were adopted by Elmyra Duff from Tiny Toon Adventures. The result, an episode titled "Yule Be Sorry", features a twist on the It's a Wonderful Life story in which Brain wishes he never met Pinky. He then has a dream in which Acme Labs was never destroyed, but Elmyra is still tormenting him there instead. When he wakes up from this nightmare, Brain apologizes to Pinky for his outburst.