In the Hanna-Barbera animated series based on the games, the ghosts were naturally featured as recurring antagonists, appearing as the henchmen of a higher ghost villain named Mezmeron (an idea that would appear with new villains in later Pac-Man games). For some reason, Clyde was made the leader of the group instead of Blinky. The quartet were also joined by Sue, a female ghost who originated as a counterpart to Clyde in the Ms. Pac-Man game, but made into a completely different character for the cartoon.
Two decades later, in the newer animated series Pac-Man and the Ghostly Adventures, the four Ghosts (minus Sue) again appeared as the henchmen of a new villain, in this case Lord Betrayus. Unlike previous iterations, though, the Ghostly Adventures versions of the Ghosts are more good-natured and even supply the teenaged Pac-Man with information about Betrayus' schemes.
Appearances in Christmas specials
Pac-Man and the Ghostly Adventures
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